Danazol Treatment for Telomere Diseases | Zendy

Danielle M. Townsley | Zendy; Bogdan Dumitriu | Zendy; Delong Liu | Zendy; Angélique Biancotto | Zendy; Barbara Weinstein | Zendy; Christina Chen | Zendy; Nathan Hardy | Zendy; Andrew D. Mihalek | Zendy; Shilpa Lingala | Zendy; Yun Ju Kim | Zendy; Jianhua Yao | Zendy; E. Ellen Jones | Zendy; Bernadette R. Gochuico | Zendy; Theo Heller | Zendy; Colin O. Wu | Zendy; Rodrigo T. Calado | Zendy; Phillip Scheinberg | Zendy; Neal S. Young | Zendy

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Danazol Treatment for Telomere Diseases

Author(s) -

Danielle M. Townsley,

Bogdan Dumitriu,

Delong Liu,

Angélique Biancotto,

Barbara Weinstein,

Christina Chen,

Nathan Hardy,

Andrew D. Mihalek,

Shilpa Lingala,

Yun Ju Kim,

Jianhua Yao,

E. Ellen Jones,

Bernadette R. Gochuico,

Theo Heller,

Colin O. Wu,

Rodrigo T. Calado,

Phillip Scheinberg,

Neal S. Young

Publication year - 2016

Publication title -

new england journal of medicine

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1515319

Subject(s) - danazol , clinical endpoint , medicine , telomere , telomerase , cancer , gastroenterology , cirrhosis , prospective cohort study , oncology , biology , clinical trial , gene , endometriosis , biochemistry

Genetic defects in telomere maintenance and repair cause bone marrow failure, liver cirrhosis, and pulmonary fibrosis, and they increase susceptibility to cancer. Historically, androgens have been useful as treatment for marrow failure syndromes. In tissue culture and animal models, sex hormones regulate expression of the telomerase gene.

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