Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease | Zendy

Frederick E. Dewey | Zendy; Viktoria Gusarova | Zendy; Colm O’Dushlaine | Zendy; Omri Gottesman | Zendy; Jesus Trejos | Zendy; Charleen Hunt | Zendy; Cristopher V. Van Hout | Zendy; Lukas Habegger | Zendy; David G. Buckler | Zendy; Ka-Man V. Lai | Zendy; Joseph B. Leader | Zendy; Michael F. Murray | Zendy; Marylyn D. Ritchie | Zendy; H. Lester Kirchner | Zendy; David H. Ledbetter | Zendy; John S. Penn | Zendy; Alexander Lopez | Zendy; Ingrid B. Borecki | Zendy; John D. Overton | Zendy; Jeffrey G. Reid | Zendy; David J. Carey | Zendy; Andrew Murphy | Zendy; George D. Yancopoulos | Zendy; Aris Baras | Zendy; Jesper Gromada | Zendy; Alan R. Shuldiner | Zendy

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Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

Author(s) -

Frederick E. Dewey,

Viktoria Gusarova,

Colm O’Dushlaine,

Omri Gottesman,

Jesus Trejos,

Charleen Hunt,

Cristopher V. Van Hout,

Lukas Habegger,

David G. Buckler,

Ka-Man V. Lai,

Joseph B. Leader,

Michael F. Murray,

Marylyn D. Ritchie,

H. Lester Kirchner,

David H. Ledbetter,

John S. Penn,

Alexander Lopez,

Ingrid B. Borecki,

John D. Overton,

Jeffrey G. Reid,

David J. Carey,

Andrew Murphy,

George D. Yancopoulos,

Aris Baras,

Jesper Gromada,

Alan R. Shuldiner

Publication year - 2016

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1510926

Subject(s) - medicine , coronary artery disease , odds ratio , angptl4 , endocrinology , triglyceride , missense mutation , cholesterol , pcsk9 , lipoprotein , genetics , biology , mutation , gene , ldl receptor

Higher-than-normal levels of circulating triglycerides are a risk factor for ischemic cardiovascular disease. Activation of lipoprotein lipase, an enzyme that is inhibited by angiopoietin-like 4 (ANGPTL4), has been shown to reduce levels of circulating triglycerides.

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