Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus | Zendy

Argyro Syngelaki | Zendy; K. H. Nicolaides | Zendy; Jyoti Balani | Zendy; Steve Hyer | Zendy; Ranjit Akolekar | Zendy; Reena Kotecha | Zendy; Alice Pastides | Zendy; Hassan Shehata | Zendy

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Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus

Author(s) -

Argyro Syngelaki,

K. H. Nicolaides,

Jyoti Balani,

Steve Hyer,

Ranjit Akolekar,

Reena Kotecha,

Alice Pastides,

Hassan Shehata

Publication year - 2016

Publication title -

new england journal of medicine

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1509819

Subject(s) - medicine , metformin , gestational diabetes , pregnancy , body mass index , obstetrics , placebo , gestation , diabetes mellitus , birth weight , preeclampsia , weight gain , endocrinology , body weight , alternative medicine , pathology , biology , genetics

Obesity is associated with an increased risk of adverse pregnancy outcomes. Lifestyle-intervention studies have not shown improved outcomes. Metformin improves insulin sensitivity and in pregnant patients with gestational diabetes it leads to less weight gain than occurs in those who do not take metformin.

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