Open AccessCorticosteroid Suppression of VEGF-A in Infantile Hemangioma-Derived Stem Cells
Author(s) -
Shoshana Greenberger,
Elisa Boscolo,
Irit Adini,
John B. Mulliken,
Joyce Bischoff
Publication year - 2010
Publication title -
new england journal of medicine/the new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa0903036
Subject(s) - vasculogenesis , medicine , stem cell , angiogenesis , hemangioma , vascular endothelial growth factor , in vivo , cancer research , pathology , biology , microbiology and biotechnology , progenitor cell , vegf receptors
Corticosteroids are commonly used to treat infantile hemangioma, but the mechanism of action of this therapy is unknown. We investigated the effect of corticosteroids in a previously described in vivo model of infantile hemangioma and in cultured hemangioma-derived cells.