Open AccessIndependent Clonal Origins of Distinct Tumor Foci in Multifocal Papillary Thyroid Carcinoma
Author(s) -
Trisha M. Shattuck,
William H. Westra,
Paul W. Ladenson,
Andrew Arnold
Publication year - 2005
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa044190
Subject(s) - thyroid carcinoma , papillary carcinoma , pathology , thyroid , thyroid cancer , medicine , carcinoma , papillary thyroid cancer , cancer research , biology
Papillary thyroid carcinoma is frequently multifocal. We investigated whether noncontiguous tumor foci arise from intraglandular metastases from a single primary tumor or originate as unrelated clones derived from independent precursors.
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