The Effect of Dexrazoxane on Myocardial Injury in Doxorubicin-Treated Children with Acute Lymphoblastic Leukemia | Zendy

Steven E. Lipshultz | Zendy; Nader Rifai | Zendy; Virginia Dalton | Zendy; Donna E. Levy | Zendy; Lewis B. Silverman | Zendy; Stuart R. Lipsitz | Zendy; Steven D. Colan | Zendy; Barbara L. Asselin | Zendy; Ronald D. Barr | Zendy; Luis A. Clavell | Zendy; Craig A. Hurwitz | Zendy; Albert Moghrabi | Zendy; Yvan Samson | Zendy; Marshall A. Schorin | Zendy; Richard D. Gelber | Zendy; Stephen E. Sallan | Zendy

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The Effect of Dexrazoxane on Myocardial Injury in Doxorubicin-Treated Children with Acute Lymphoblastic Leukemia

Author(s) -

Steven E. Lipshultz,

Nader Rifai,

Virginia Dalton,

Donna E. Levy,

Lewis B. Silverman,

Stuart R. Lipsitz,

Steven D. Colan,

Barbara L. Asselin,

Ronald D. Barr,

Luis A. Clavell,

Craig A. Hurwitz,

Albert Moghrabi,

Yvan Samson,

Marshall A. Schorin,

Richard D. Gelber,

Stephen E. Sallan

Publication year - 2004

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa035153

Subject(s) - dexrazoxane , doxorubicin , medicine , troponin i , troponin , chemotherapy , anthracycline , troponin t , urology , surgery , gastroenterology , cancer , myocardial infarction , breast cancer

Doxorubicin chemotherapy is very effective in children with acute lymphoblastic leukemia (ALL) but also injures myocardial cells. Dexrazoxane, a free-radical scavenger, may protect the heart from doxorubicin-associated damage.

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