The Interval between Pregnancies and the Risk of Preeclampsia | Zendy

Rolv Skjærven | Zendy; Allen J. Wilcox | Zendy; Rolv T. Lie | Zendy

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The Interval between Pregnancies and the Risk of Preeclampsia

Author(s) -

Rolv Skjærven,

Allen J. Wilcox,

Rolv T. Lie

Publication year - 2002

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa011379

Subject(s) - medicine , preeclampsia , obstetrics , pregnancy , odds ratio , confidence interval , singleton , relative risk , population , gynecology , demography , genetics , environmental health , sociology , biology

The risk of preeclampsia is generally lower in second pregnancies than in first pregnancies, but not if the mother has a new partner for the second pregnancy. One explanation is that the risk is reduced with repeated maternal exposure and adaptation to specific antigens from the same partner. However, the difference in risk might instead be explained by the interval between births. A longer interbirth interval may be associated with both a change of partner and a higher risk of preeclampsia.

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