Open AccessReversal of Catabolism by Beta-Blockade after Severe Burns
Author(s) -
David N. Herndon,
David W. Hart,
Steven E. Wolf,
David L. Chinkes,
Robert R. Wolfe
Publication year - 2001
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa010342
Subject(s) - propranolol , medicine , blockade , resting energy expenditure , endocrinology , basal metabolic rate , catabolism , heart rate , protein catabolism , skeletal muscle , anesthesia , energy expenditure , metabolism , blood pressure , biology , biochemistry , receptor , amino acid
The catecholamine-mediated hypermetabolic response to severe burns causes increased energy expenditure and muscle-protein catabolism. We hypothesized that blockade of beta-adrenergic stimulation with propranolol would decrease resting energy expenditure and muscle catabolism in patients with severe burns.
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