Open AccessA Novel Synthesis of Hemispherands
Author(s) -
Ryszard Ostaszewski,
Willem Verboom,
David N. Reinhoudt
Publication year - 1992
Publication title -
synlett
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.712
H-Index - 133
eISSN - 1437-2096
pISSN - 0936-5214
DOI - 10.1055/s-1992-22013
Subject(s) - chemistry , palladium , ring (chemistry) , suzuki reaction , potassium , combinatorial chemistry , catalysis , sodium , stereochemistry , organic chemistry
A novel, flexible synthesis of hemispherands {2,5,8-trioxa[9](3,3″) m-terphenylophanes 5a-d} with different central aromatic groups is described. The key step comprises the introduction of the central aromatic ring in the last step of the synthesis via a Suzuki cross-coupling reaction using palladium tetrakis(triplienylphosphine) as a catalyst and sodium or potassium cations serving as a template ion in the macrocyclization
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