Open AccessRadiation-Induced Tissue Damage: Clinical Consequences and Current Treatment Options
Author(s) -
Hillary Nepon,
Tyler Safran,
Edward M. Reece,
Amanda Murphy,
Joshua Vorstenbosch,
Peter Davison
Publication year - 2021
Publication title -
seminars in plastic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.5
H-Index - 25
eISSN - 1536-0067
pISSN - 1535-2188
DOI - 10.1055/s-0041-1731464
Subject(s) - medicine , osteoradionecrosis , radiation therapy , treatment modality , pathophysiology , radiation injury , intensive care medicine , surgery , pathology
Radiation therapy is a valuable tool in the treatment of numerous malignancies but, in certain cases, can also causes significant acute and chronic damage to noncancerous neighboring tissues. This review focuses on the pathophysiology of radiation-induced damage and the clinical implications it has for plastic surgeons across breast reconstruction, osteoradionecrosis, radiation-induced skin cancers, and wound healing. The current understanding of treatment modalities presented here include hyperbaric oxygen therapy, autologous fat grafting and stem cells, and pharmaceutical agents.