Open AccessWhen Benign Becomes Cancer: Malignant Degeneration of Chronic Inflammation
Author(s) -
Christopher P. Conlon,
Lauren Pupa,
Edward M. Reece,
Carrie K. Chu,
Jessie Z. Yu,
Joshua Vorstenbosch,
Sebastian Winocour
Publication year - 2021
Publication title -
seminars in plastic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.5
H-Index - 25
eISSN - 1536-0067
pISSN - 1535-2188
DOI - 10.1055/s-0041-1731462
Subject(s) - medicine , inflammation , malignancy , sarcoma , degeneration (medical) , cancer , lymphoma , pathology , radiation therapy , immunology
Chronic inflammation, long implicated in the genesis of malignancy, is now understood to underlie an estimated 25% of all cancers. The most pertinent malignancies, to the plastic surgeon, associated with the degeneration of chronic inflammation include Marjolin's ulcer, breast implant-associated large cell lymphoma, radiation-induced sarcoma, and Kaposi's sarcoma. The cellular and genetic damage incurred by a prolonged inflammatory reaction is controlled by an increasingly understood cytokinetic system. Advances in understanding the chronic inflammatory cascade have yielded new therapeutics and therapeutic targets.