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Smell Regions in Patients with Vitamin D Deficiency: An MRI Evaluation
Author(s) -
Ziya Şencan,
Nuray Bayar Muluk,
Mehmet Hamdi Şahan
Publication year - 2021
Publication title -
journal of neurological surgery. part b, skull base
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.488
H-Index - 42
eISSN - 2193-6331
pISSN - 2193-634X
DOI - 10.1055/s-0040-1722227
Subject(s) - medicine , vitamin d deficiency , vitamin d and neurology
Objective  We investigated the effects of vitamin D deficiency in the peripheral and central smell regions by magnetic resonance imaging (MRI). Methods  This retrospective study included 29 patients (12 males, 17 females) with 25-dihydroxy vitamin D3 [25(OH) 2 D 3 ] deficiency (group 1) and 34 subjects without 25(OH) 2 D 3 deficiency (14 males, 20 females) (group 2). Using cranial MRIs, the peripheral (olfactory bulb [OB] volume and olfactory sulcus [OS] depth) and central (insular gyrus and corpus amygdala) smell regions were evaluated. Results  The OB volume and OS depth values of the 25(OH) 2 D3 deficiency group were significantly lower than those of the control group ( p  < 0.05). For the central smell regions, the insular gyrus and corpus amygdala areas of the 25(OH) 2 D3 deficiency group were nonsignificantly lower than those in the control group ( p  > 0.05). There were positive correlations between OB volumes, OS depths, and insular gyrus and corpus amygdala areas bilaterally in the 25(OH) 2 D3 deficiency group separately and in all subjects (groups 1 and 2) ( p  < 0.05). In the 25(OH) 2 D3 deficiency group, as the 25(OH) 2 D3 values became lower, the insular gyrus area values decreased bilaterally ( p  < 0.05). In females, the corpus amygdala area values were lower than in males ( p  < 0.05). Conclusion  Since vitamin D3 deficiency affected the peripheral and central smell regions negatively, we recommend evaluating patients' vitamin D levels as a health policy to prevent vitamin D3 deficiency-related cranial smell region problems. Moreover, sunlight exposure is very important to increase vitamin D levels, and the public should be informed about this topic.

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