Open AccessAsymmetric Reductive Dicarbofunctionalization of Alkenes via Nickel Catalysis
Author(s) -
David R. Anthony,
Tianning Diao
Publication year - 2020
Publication title -
synlett
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.712
H-Index - 133
eISSN - 1437-2096
pISSN - 0936-5214
DOI - 10.1055/s-0040-1707900
Subject(s) - chemistry , alkene , catalysis , reagent , reductive elimination , combinatorial chemistry , nickel , selectivity , functional group , transition metal , organic chemistry , polymer
Alkenes are an appealing functional group that can be transformed into a variety of structures. Transition-metal catalyzed dicarbofunctionalization of alkenes can efficiently afford products with complex substitution patterns from simple substrates. Under reductive conditions, this transformation can be achieved while avoiding stoichiometric organometallic reagents. Asymmetric difunctionalization of alkenes has been underdeveloped, in spite of its potential synthetic utility. Herein, we present a summary of our efforts to control enantioselectivity for alkene diarylation with a nickel catalyst. This reaction is useful for preparing triarylethanes. The selectivity is enhanced by an N -oxyl radical additive.