Open AccessThe Effects of Furosemide on Oxygenation in Mechanically Ventilated Children with Bronchiolitis
Author(s) -
Mandar Kulkarni,
Katherine Slain,
Alexandre T. Rotta,
Steven Shein
Publication year - 2019
Publication title -
journal of pediatric intensive care
Language(s) - English
Resource type - Journals
eISSN - 2146-4618
pISSN - 2146-4626
DOI - 10.1055/s-0039-3400467
Subject(s) - furosemide , medicine , interquartile range , diuretic , oxygenation , bronchiolitis , anesthesia , mechanical ventilation , respiratory system
Fluid balance management, including diuretic administration, may influence outcomes among mechanically ventilated children. We retrospectively compared oxygenation saturation index (OSI) before and after the initial furosemide bolus among 65 mechanically ventilated children. Furosemide was not associated with a significant change in median OSI (6.25 [interquartile range: 5.01-7.92] vs. 6.06 [4.73-7.54], p = 0.48), but was associated with expected changes in fluid balance and urine output. Secondary analysis suggested more favorable effects of furosemide in children with worse baseline OSI. The reported common use of furosemide by pediatric intensivists obligates further study to better establish its efficacy, or lack thereof, in mechanically ventilated children.