Open AccessSevere Hyponatraemia Associated with the Use of Arginine–Vasopressin in Two Neonates with Complex Congenital Heart Disease
Author(s) -
Nicolas Leister,
Daniel E. Rohe,
Christie Schumacher,
Uwe Trieschmann,
Christoph Menzel,
Tobias Hannes
Publication year - 2020
Publication title -
journal of pediatric intensive care
Language(s) - English
Resource type - Journals
eISSN - 2146-4618
pISSN - 2146-4626
DOI - 10.1055/s-0039-1700963
Subject(s) - vasopressin , medicine , hyponatremia , arginine , heart disease , discontinuation , shock (circulatory) , heart failure , cardiology , endocrinology , amino acid , biochemistry , chemistry
We report two cases of neonates with complex congenital heart disease and volume, catecholamine, and corticosteroid refractory shock treated with arginine-vasopressin. Arginine-vasopressin was able to reverse critical hypotension, but both patients developed severe hyponatremia, which recovered after discontinuation of arginine-vasopressin. Close control and prompt substitution of serum sodium is required in neonates with advanced heart failure on high-dose vasopressin therapy.