Open AccessThe 22q11.2 Microdeletion in Pediatric Patients with Cleft Lip, Palate, or Both and Congenital Heart Disease: A Systematic Review
Author(s) -
Diana Cárdenas-Nieto,
Maribel Forero-Castro,
Clara Esteban-Pérez,
Julio Martínez-Lozano,
Ignacio BriceñoBalcázar
Publication year - 2019
Publication title -
journal of pediatric genetics
Language(s) - English
Resource type - Journals
eISSN - 2146-4596
pISSN - 2146-460X
DOI - 10.1055/s-0039-1698804
Subject(s) - medicine , deletion syndrome , pediatrics , quality of life (healthcare) , heart disease , disease , digeorge syndrome , genetics , psychiatry , nursing , gene , biology , phenotype
The 22q11.2 deletion syndrome (22q11.2DS) is present in approximately 5 to 8% of patients with cleft lip, palate, or both (CL/P) and 75 to 80% of patients with congenital heart disease (CHD). In a literature review, we consider this association of 22q11.2DS in pediatric patients with CL/P and CHD. Early diagnosis of 22q11.2DS in pediatric patients with CL/P and CHD helps to optimize a multidisciplinary treatment approach for 22q11DS. Early diagnosis, thereby, can improve quality of life for these patients and awareness of other potential clinical implications that may require attention throughout the patient's life.