Open AccessApolipoprotein B100/Low-Density Lipoprotein Regulates Proteolysis and Functions of von Willebrand Factor under Arterial Shear
Author(s) -
Wenjing Cao,
Mohammad S. Abdelgawwad,
Jingzhi Li,
X. Long Zheng
Publication year - 2019
Publication title -
thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.97
H-Index - 188
eISSN - 2567-689X
pISSN - 0340-6245
DOI - 10.1055/s-0039-1696713
Subject(s) - adamts13 , von willebrand factor , chemistry , apolipoprotein b , proteolysis , lipoprotein , biochemistry , platelet , low density lipoprotein , glycoprotein ib , microbiology and biotechnology , medicine , platelet membrane glycoprotein , glycoprotein , cholesterol , biology , enzyme
Proteolytic cleavage of von Willebrand factor (VWF) by a plasma a disintegrin and metalloproteinase with a thrombospondin type 1 motifs, member 13 (ADAMTS13) is regulated by shear stress and binding of coagulation factor VIII, platelets or platelet glycoprotein 1b, and ristocetin to VWF.