Open AccessPrescribing Patterns of Continuous Infusions in Nonobese versus Obese Children Admitted to the Pediatric Intensive Care Unit
Author(s) -
Peter N. Johnson,
Katy Stephens,
Philip A. Barker,
Erica Bergeron,
Sin Yin Lim,
Tracy M. Hagemann,
Teresa V. Lewis,
Stephen Neely,
Jamie L. Miller
Publication year - 2019
Publication title -
journal of pediatric intensive care
Language(s) - English
Resource type - Journals
eISSN - 2146-4618
pISSN - 2146-4626
DOI - 10.1055/s-0039-1692669
Subject(s) - medicine , midazolam , propofol , fentanyl , anesthesia , dosing , sedation , intensive care unit , pharmacokinetics , pediatric intensive care unit , pharmacodynamics , neuromuscular blockade , continuous infusion , retrospective cohort study , pediatrics
This retrospective study compared the continuous infusions prescribed for obese and nonobese children. Ninety-five (13.2%) received an infusion. A greater percentage of obese ( n = 42/168) versus nonobese (53/552) children received infusions, p < 0.01. No difference was noted in the median number of infusions between the obese and nonobese groups, 2 versus 2, p = 0.975. The top 20 prescribed infusions included ten (50%) for sedation/analgesia or neuromuscular blockade and six (30%) for hemodynamic support. A literature search was performed for these 20 agents to determine pharmacokinetics, pharmacodynamics, and dosing in obese children and revealed six studies evaluating fentanyl ( n = 2), midazolam ( n = 1), and propofol ( n = 3).