Open AccessRhodium(III)-Catalyzed Cyclopropanation of Unactivated Olefins Initiated by C–H Activation
Author(s) -
Erik J. T. Phipps,
Tiffany Piou,
Tomislav Rovis
Publication year - 2019
Publication title -
synlett
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.712
H-Index - 133
eISSN - 1437-2096
pISSN - 0936-5214
DOI - 10.1055/s-0039-1690130
Subject(s) - cyclopropanation , rhodium , chemistry , alkene , carbene , catalysis , medicinal chemistry , stoichiometry , organic chemistry
We have developed a Rh(III)-catalyzed cyclopropanation of unactivated olefins initiated by an alkenyl C-H activation. A variety of 1,1-disubstituted olefins undergo efficient cyclopropanation with a slight excess of alkene stoichiometry. A series of mechanistic interrogations implicate a metal-carbene as an intermediate.