Open AccessGrowing teratoma syndrome: A case report
Author(s) -
Sumedha Gupta,
Saritha Shamsunder,
Roli Purwar,
Vidya Jha,
Amit Kumar Yadav,
Sunita Malik,
Rakesh Bihari Verma,
Sant Parkash Kataria
Publication year - 2016
Publication title -
asian journal of oncology
Language(s) - English
Resource type - Conference proceedings
eISSN - 2455-4618
pISSN - 2454-6798
DOI - 10.1055/s-0039-1685323
Subject(s) - histopathology , laparotomy , chemotherapy , teratoma , medicine , adnexal mass , germ cell tumors , ascites , immature teratoma , metastasis , surgery , pathology , cancer
Growing teratoma syndrome (GTS) or chemotherapeutic retro conversion is an extremely rare phenomenon seen in about 1.9-7.6% of patients being treated for non-seminomatous testicular germ cell tumor. It is even more rarely reported in females with only sporadic cases reported so far. It was described by logothetis et al and is described as conversion of immature teratoma to mature one after chemotherapy and presents as growing and metastasizing mass. Case Report: We report a case of 10 year old girl who underwent conservative surgery for an adnexal mass reported as immature teratoma on histopathology. Following which she was given chemotherapy for rapidly developing ascites. After four cycles of chemotherapy, the pelvic mass increased in size with metastatic deposits around the liver. Re-laparotomy and removal of the ovarian mass and metastatic deposits was carried out in stages. The histopathology showed mature teratoma. Conclusion: GTS is an extremely rare occurrence and it is important for the clinicians to know it to avoid misdiagnosis. Moreover, being a chemo-resistant tumor, early diagnosis and surgery are curative.