Synthesis and Antimicrobial/Cytotoxic Assessment of Ferrocenyl Oxazinanes, Oxazinan-2-ones, and Tetrahydropyrimidin-2-ones | Zendy

Rastko D. Vukićević | Zendy; Matthias D’hooghe | Zendy; Anka Pejović | Zendy; Barbara Danneels | Zendy; Tom Desmet | Zendy; Ba Thi Cham | Zendy; Tuyen Van Nguyen | Zendy; Niko S. Radulović | Zendy

Open Access

Synthesis and Antimicrobial/Cytotoxic Assessment of Ferrocenyl Oxazinanes, Oxazinan-2-ones, and Tetrahydropyrimidin-2-ones

Author(s) -

Rastko D. Vukićević,

Matthias D’hooghe,

Anka Pejović,

Barbara Danneels,

Tom Desmet,

Ba Thi Cham,

Tuyen Van Nguyen,

Niko S. Radulović

Publication year - 2015

Publication title -

synlett

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.712

H-Index - 133

eISSN - 1437-2096

pISSN - 0936-5214

DOI - 10.1055/s-0034-1380348

Subject(s) - chemistry , antimicrobial , ferrocene , combinatorial chemistry , organic chemistry , cytotoxic t cell , biochemistry , in vitro , electrochemistry , electrode

3-Arylamino-1-ferrocenylpropan-1-ones, prepared through aza-Michael addition of aromatic amines to 1-ferrocenylpropenone, were transformed into the corresponding 1,3-amino alcohols upon NaBH4-mediated carbonyl reduction. The latter amino alcohols were deployed as eligible substrates for the synthesis of a variety of ferrocene-containing heterocycles including 1,3-oxazinanes, 1,3-oxazinan-2-ones, and tetrahydropyrimidin-2-ones, which were subsequently evaluated for their antimicrobial and cytotoxic activities

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