Open AccessMaternal Periodontal Disease is Associated with Oxidative Stress during Pregnancy
Author(s) -
M. Ashley Hickman,
Kim Boggess,
Kevin Moss,
James D. Beck,
Steven Offenbacher
Publication year - 2010
Publication title -
american journal of perinatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 67
eISSN - 1098-8785
pISSN - 0735-1631
DOI - 10.1055/s-0030-1268706
Subject(s) - medicine , isoprostane , pregnancy , interquartile range , odds ratio , oxidative stress , confidence interval , logistic regression , physiology , gastroenterology , obstetrics , lipid peroxidation , biology , genetics
We sought to determine if maternal periodontal disease is associated with oxidative stress as measured by serum 8-isoprostane. A secondary analysis was conducted using prospective data from the Oral Conditions and Pregnancy Study. Healthy women enrolled at < 26 weeks' gestational age underwent oral examination and serum sampling. Maternal periodontal disease status was categorized as healthy, mild, or moderate to severe by clinical criteria. Maternal serum was analyzed for 8-isoprostane using ultrasensitive enzyme-linked immunosorbent assay. Elevated 8-isoprostane level was defined as ≥ 75th percentile. Maternal factors associated with elevated 8-isoprostane were determined using chi-square or T test. Multivariable logistic regression was used to assess association between elevated 8-isoprostane and maternal factors. Seven hundred ninety-one women had complete data. Median (interquartile) 8-isoprostane serum level was 1806 (16 to 81,870) pg/dL. Using bivariate analysis, maternal age, race, marital status, utilization of public assistance, and mild or moderate to severe periodontal disease were associated with elevated serum 8-isoprostane. Using logistic regression, moderate to severe periodontal disease (adjusted odds ratio 2.9, 95% confidence interval: 1.7 to 5.0) remained significantly associated with an elevated serum 8-isoprostane level. Maternal periodontal disease is associated with oxidative stress during pregnancy. Further study is needed to determine the role of maternal oxidative stress in periodontal disease-associated adverse pregnancy outcomes.