Open AccessCondensation-Based Methods for the C–H Bond Functionalization of Amines
Author(s) -
Weijie Chen,
Daniel Seidel
Publication year - 2021
Publication title -
synthesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.885
H-Index - 140
eISSN - 1437-210X
pISSN - 0039-7881
DOI - 10.1055/a-1631-2140
Subject(s) - chemistry , surface modification , isomerization , cyclic amines , redox , condensation reaction , strecker amino acid synthesis , condensation , mannich reaction , combinatorial chemistry , organic chemistry , amine gas treating , catalysis , enantioselective synthesis , physics , thermodynamics
This review aims to provide a comprehensive overview of condensation-based methods for the C-H bond functionalization of amines that feature azomethine ylides as key intermediates. These transformations are typically redox-neutral and share common attributes with classic name reactions such as the Strecker, Mannich, Friedel-Crafts, Pictet-Spengler, and Kabachnik-Fields reaction, while incorporating a redox-isomerization step. This approach provides an ideal platform to rapidly transform simple starting materials into complex amines.