
Targeting Tryptophan for Tagging through Photoinduced Electron Transfer
Author(s) -
Norberto V. Orellana,
Michael T. Taylor
Publication year - 2021
Publication title -
synlett
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.712
H-Index - 133
eISSN - 1437-2096
pISSN - 0936-5214
DOI - 10.1055/a-1479-6366
Subject(s) - chemistry , bioconjugation , tryptophan , photoinduced electron transfer , context (archaeology) , pyridinium , electron transfer , combinatorial chemistry , photochemistry , amino acid , organic chemistry , biochemistry , paleontology , biology
The chemical modification of tryptophan (Trp) has been the subject of interest for nearly 100 years, yet the development modification conditions that exploit Trp's inherent photolability have remained elusive. In this perspective, we discuss our recently reported method for Tryptophan (Trp) photobioconjugation that uses N -carbamoyl pyridinium salts to engage Trp in photo-induced electron transfer. We detail our inspiration and rationale as well as place our report in the context of select prior art in the field.