Open AccessModular Synthesis of Streptogramin Antibiotics
Author(s) -
Qi Li,
Ian B. Seiple
Publication year - 2020
Publication title -
synlett
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.712
H-Index - 133
eISSN - 1437-2096
pISSN - 0936-5214
DOI - 10.1055/a-1293-9655
Subject(s) - polyketide , chemistry , antibiotics , nonribosomal peptide , streptomyces , stereochemistry , bacteria , computational biology , combinatorial chemistry , biochemistry , biosynthesis , biology , genetics , gene
Streptogramins are antibiotics produced by several species of Streptomyces bacteria that are used in both human and veterinary medicine. Group A streptogramins comprise 23-membered macrocyclic polyketide/nonribosomal peptide hybrids for which several innovative, fully synthetic routes have been developed. Herein we describe in detail our scalable routes to natural group A streptogramins and compare these routes to other reported syntheses.