Modular Synthesis of Streptogramin Antibiotics | Zendy

Qi Li | Zendy; Ian B. Seiple | Zendy

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Modular Synthesis of Streptogramin Antibiotics

Author(s) -

Qi Li,

Ian B. Seiple

Publication year - 2020

Publication title -

synlett

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.712

H-Index - 133

eISSN - 1437-2096

pISSN - 0936-5214

DOI - 10.1055/a-1293-9655

Subject(s) - polyketide , chemistry , antibiotics , nonribosomal peptide , streptomyces , stereochemistry , bacteria , computational biology , combinatorial chemistry , biochemistry , biosynthesis , biology , genetics , gene

Streptogramins are antibiotics produced by several species of Streptomyces bacteria that are used in both human and veterinary medicine. Group A streptogramins comprise 23-membered macrocyclic polyketide/nonribosomal peptide hybrids for which several innovative, fully synthetic routes have been developed. Herein we describe in detail our scalable routes to natural group A streptogramins and compare these routes to other reported syntheses.

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