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A novel self-assembling peptide for hemostasis during endoscopic submucosal dissection: a randomized controlled trial
Author(s) -
Sharmila Subramaniam,
Kesavan Kandiah,
Fergus Chedgy,
Carole Fogg,
Sreedhari Thayalasekaran,
Asma Alkandari,
Michelle Baker-Moffatt,
Joanne Dash,
Mark Lyons-Amos,
Gaius Longcroft–Wheaton,
J F Brown,
Pradeep Bhandari
Publication year - 2020
Publication title -
endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.78
H-Index - 143
eISSN - 1438-8812
pISSN - 0013-726X
DOI - 10.1055/a-1198-0558
Subject(s) - medicine , hemostasis , hemostat , surgery , randomized controlled trial , diathermy , endoscopy , endoscopic submucosal dissection , cryotherapy , dissection (medical) , wound healing , endoscopic mucosal resection
Endoscopic submucosal dissection (ESD) is associated with a risk of bleeding. Bleeding is usually treated with diathermy, although this does carry a risk of mucosal thermal injury. Purastat is a topical hemostat that may be effective in controlling bleeding during ESD, thereby reducing the use of heat therapy. The aim of this study was to assess the reduction in heat therapy used in the interventional group (Purastat) compared with the control group. The secondary aims were to compare the procedure length, time for hemostasis, delayed bleeding rate, adverse events, and wound healing between the groups.

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