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Delayed recurrence of hepatocellular carcinoma after liver transplantation: Detection of origin by chromosomal analysis
Author(s) -
AlJoundi Tammam,
Gibson Sandra,
Brunt Elizabeth M.,
Shakil Obaid,
Lee Randall S.,
Di Bisceglie Adrian M.
Publication year - 2000
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1053/lv.2000.5202
Subject(s) - hepatocellular carcinoma , medicine , liver transplantation , dysplasia , transplantation , pathology , carcinoma , gastroenterology
Abstract We report on a 41‐year‐old man undergoing liver transplantation for chronic hepatitis C who presented 26 months later with hepatocellular carcinoma. No evidence of hepatocellular carcinoma could be found in the native liver, although features of small cell dysplasia were prominent. Although he had recurrent hepatitis C, the transplanted liver was not cirrhotic. Chromosomal analysis was used to resolve whether this was a de novo tumor or a recurrence of an unsuspected tumor present at the time of transplantation. This male patient had received a liver from a female donor, and in situ hybridization for the Y chromosome showed reactivity in the tumor but not in surrounding nontumorous liver. Thus, this is an example of the use of chromosomal analysis to resolve the origin of a tumor occurring in the transplant setting.