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Use of Atropine to Reduce Mucosal Eversion During Intestinal Resection and Anastomosis in the Dog
Author(s) -
Agrodnia Marta,
Hauptman Joe,
Walshaw Richard
Publication year - 2003
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1053/jvet.2003.50041
Subject(s) - atropine , medicine , jejunum , anastomosis , saline , beagle , anesthesia , premedication , surgery
Objective— To determine whether atropine altered the degree of mucosal eversion during jejunal resection and anastomosis in the dog. Study Design— Part I: Prospective, blinded, randomized, controlled study using a therapeutic dose (0.04 mg/kg systemic) of atropine. Part II: Prospective, unblinded, assigned, controlled study using a pharmacologic (0.04 mg/kg local arterial) dose of atropine. Animals— Part I: Twenty‐two young adult female Beagle dogs used during a nonsurvival third‐year veterinary student surgical laboratory (small intestinal resection and anastomosis). Part II: Ten young adult female Beagle dogs used immediately after completion of a nonsurvival third‐year veterinary student orthopedic surgical laboratory. Methods— Part I: Dogs were randomly assigned to receive either atropine (0.04 mg/kg), or an equal volume of saline, given intramuscularly (premedication) and again intravenously prior to intestinal resection. Part II: In each dog, atropine (0.04 mg/kg)/saline was alternately given in the proximal/distal jejunum. Results— Part I: There was no clinically or statistically significant difference between systemic atropine and saline solution on the degree of jejunal mucosal eversion after resection. Part II: There was a statistically significant decrease in jejunal mucosal eversion with atropine compared with saline solution when injected into a local jejunal artery. Conclusion— Systemic atropine (0.04 mg/kg) does not alter the degree of jejunal mucosal eversion during resection and anastomosis. Jejunal intraarterial atropine (0.04 mg/kg) reduced jejunal mucosal eversion during resection and anastomosis. Clinical Relevance— The clinical usefulness and consequences of jejunal arterial atropine administration to reduce mucosal eversion remain to be determined.