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The Effects of a Hemoglobin‐Based Oxygen Carrier (HBOC‐301) on Left Ventricular Systolic Function in Anesthetized Dogs
Author(s) -
Muir William W.,
Autran Helio S.,
Constable Peter D.
Publication year - 2000
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1053/jvet.2000.9137
Subject(s) - medicine , preload , cardiac output , stroke volume , cardiology , blood pressure , afterload , heart rate , anesthesia , vascular resistance , mean arterial pressure , cardiac function curve , diastole , hemodynamics , heart failure
Objective— To evaluate the effects of a hemoglobin‐based oxygen carrier (HBOC‐301) on left ventricular preload, afterload, contractility, and ventriculo‐arterial coupling in anesthetized dogs. Study Design— A prospective experimental study. Animals— Seven adult male dogs weighing 2.3 to 2.7 kg. Methods— The study was performed on intact, closed‐chest, chloralose‐anesthetized dogs. Heart rate, left ventricular end‐systolic and end‐diastolic volume and pressure, cardiac output, stroke volume, blood resistivity, mean arterial pressure (MAP), dP/dt max , end‐systolic elastance (E es ), systemic vascular resistance (SVR), effective arterial elastance (E a ), left ventricular‐arterial coupling (E es /E a ), and myocardial oxygen consumption (MVo 2 ) were determined during a 90‐minute infusion of 30 mL/kg (20 mL/kg/h) of HBOC‐301 and for 90 minutes thereafter. Results— The administration of HBOC‐301 significantly decreased packed cell volume, blood resistivity, heart rate, cardiac output, and dP/dt max and significantly increased left ventricular end‐diastolic and end‐systolic pressure, MAP, and SVR. The E a , E es , E es /E a, and MVo 2 did not change. Conclusions— HBOC‐301 produced insignificant changes in load independent indexes of cardiac performance (E es , E a , E es /E a ) in anesthetized dogs. The collective directional changes in these variables, however, in conjunction with significant increases in SVR were most likely responsible for a decrease in cardiac output. Increases in SVR and the volume load (30 mL/kg) contributed to increases in left ventricular end‐diastolic pressure. Clinical Relevance— HBOC‐301 infusion should be monitored and administered cautiously to dogs with poor ventricular function.