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Late onset of tacrolimus‐related posterior leukoencephalopathy after living donor liver transplantation
Author(s) -
Frühauf Nils R.,
Koeppen Susanne,
Saner Fuat H.,
Egelhof Thomas,
Stavrou Gregor,
Nadalin Silvio,
Broelsch Christoph E.
Publication year - 2003
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1053/jlts.2003.50181
Subject(s) - tacrolimus , immunosuppression , medicine , liver transplantation , leukoencephalopathy , transplantation , neurotoxicity , surgery , magnetic resonance imaging , toxicity , radiology
Neurotoxicity is a well‐known side effect of tacrolimus‐based immunosuppression after liver transplantation. Until now, only 31 cases of immunosuppression‐associated leukoencephalopathy in liver transplant recipients reported in the literature are related to tacrolimus therapy. We report a patient who developed a posterior leukoencephalopathy syndrome, secondary to tacrolimus‐based immunosuppression, after living donor liver transplantation. The special features of this case are the sudden and late onset of neurologic symptoms, a persistent comatose state, and increased signal intensity in follow‐up MRI.