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Recurrent deep‐vein thrombosis based on homozygous factor V Leiden mutation acquired after liver transplantation
Author(s) -
Willems Marc,
Sterneck Martina,
Langer Florian,
Jung Roman,
Haddad Munif,
Hagel Christian,
Kuetemeier Robert,
Eifrig Barbara,
Broering Dieter,
Fischer Lutz,
Rogiers Xavier
Publication year - 2003
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1053/jlts.2003.50136
Subject(s) - medicine , liver transplantation , portal vein thrombosis , factor v leiden , gastroenterology , factor v , liver disease , venous thrombosis , hepatocellular carcinoma , transplantation , thrombosis , protein c , mutation , gene mutation , gene , genetics , biology
Abstract Several genetic liver diseases can be treated by liver transplantation (LT). However, some genetic defects also may be acquired by this procedure. We describe a patient who developed recurrent deep‐vein thromboses after LT for hepatitis C virus‐associated hepatocellular carcinoma on the basis of a homozygous Leiden mutation of the factor V gene in the donor liver. Liver donors with a history of venous thrombosis should be screened for the presence of activated protein C (APC) resistance. In addition, we recommend looking for APC resistance in liver recipients who develop venous thromboembolic disease in the post‐LT course. Molecular analysis of donor tissue may be necessary to make a definite diagnosis of factor V Leiden mutation in these patients. As a consequence, intensified postoperative thromboprophylaxis or lifelong anticoagulant therapy may be necessary if this thrombophilic gene defect is detected. ( Liver Transpl 2003;9:870‐873. )