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Acquired hemophilia A after liver transplantation: A case report
Author(s) -
Hisatake Garrett M.,
Chen TengWei,
Renz John F.,
Farmer Douglas G.,
Ghobrial R. Mark,
Yersiz Hasan,
Amado Rafael G.,
Goldstein Leonard,
Busuttil Ronald W.
Publication year - 2003
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1053/jlts.2003.50095
Subject(s) - medicine , contraindication , liver transplantation , liver disease , coagulation , transplantation , surgery , organ donation , donation , orthotopic liver transplantation , gastroenterology , pathology , alternative medicine , economics , economic growth
Abstract It is well recognized that orthotopic liver transplantation rapidly corrects the coagulation disorder observed in patients with hemophilia A or B combined with end‐stage liver disease; however, the transmission of hemophilia from a donor to a transplant recipient has not been reported previously. We describe a patient who developed acquired hemophilia A after liver transplantation due to the unknown presence of factor VIII inhibitor in the donor. The resulting coagulation disorder was unresponsive to standard factor replacement therapy, and was ultimately corrected with retransplantation. Hemophiliac donors should not be precluded from organ donation, though the presence of factor VIII inhibitor should be actively sought before organ procurement. High levels of factor VIII inhibitor represents an absolute contraindication to liver donation.