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MELD score predicts 1‐year patient survival post‐orthotopic liver transplantation
Author(s) -
Saab Sammy,
Wang Victor,
Ibrahim Ayman B.,
Durazo Francisco,
Han Steven,
Farmer Douglas G.,
Yersiz Hasan,
Morrisey Marcia,
Goldstein Leonard I.,
Ghobrial R. Mark,
Busuttil Ronald W.
Publication year - 2003
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1053/jlts.2003.50090
Subject(s) - medicine , hazard ratio , proportional hazards model , liver transplantation , liver disease , united network for organ sharing , survival analysis , model for end stage liver disease , orthotopic liver transplantation , gastroenterology , surgery , transplantation , confidence interval
The Model for End‐Stage Liver Disease (MELD) is an important predictor in patients awaiting orthotopic liver transplantation (OLT). However, the model's association with posttransplant patient survival is unclear. We studied 1‐year patient survival in 404 adult patients who underwent OLT at the University of California Los Angeles. The hazard rates of patient survival according to the MELD strata and United Network for Organ Sharing (UNOS) statuses were assessed by Proportional Hazard Cox regression analysis. The difference in survival for MELD strata and UNOS status were compared using the Cox model. There was a significant difference in 1‐year patient ( P = .0006) survival using different MELD strata, whereas there was a trend according to UNOS status ( P = .051). Increased rate of death was observed in recipients of OLT with higher MELD scores (> 36, hazard ratio 3.9; 95% CI 1.55, 10.27) and more urgent UNOS status (2A; hazard ratio, 1.99; 95% CI 1.07, 3.7). The MELD stratum is better associated with 1‐year patient survival in liver transplant recipients than UNOS statuses. Patient survival was worse with higher MELD scores.