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Evidence that a single stem cell can lead to multi‐organ engraftment
Author(s) -
Decker G. Anton G.,
Nyberg Scott L.
Publication year - 2001
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1053/jlts.2001.0071085
Subject(s) - medicine , lead (geology) , stem cell , intensive care medicine , liver transplantation , transplantation , microbiology and biotechnology , biology , paleontology
Abstract Purification of rare hematopoietic stem cells (HSC) to homogeneity is required to study their self‐renewal, differentiation, phenotype, and homing. Long‐term repopulation (LTR) of irradiated hosts and serial transplantation to secondary hosts represent the gold standard for demonstrating self‐renewal and differentiation, the defining properties of HSC. We show that rare cells that home to bone marrow can LTR primary and secondary recipients. During the homing, CD34 and SCA‐1 expression increases uniquely on cells that home to marrow. These adult bone marrow cells have tremendous differentiative capacity as they can also differentiate into epithelial cells of the liver, lung, GI tract, and skin. This finding may contribute to clinical treatment of genetic disease or tissue repair.