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Spontaneous clearance of hepatitis C virus infection post–liver transplantation is associated with rapidly changing quasispecies: A single case report
Author(s) -
Doughty Alison L.,
Zekry Amany,
Spencer Jenean D.,
Turhan Seven,
Painter Dorothy,
McCaughan Geoffrey W.
Publication year - 2000
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1053/jlts.2000.9740
Subject(s) - viral quasispecies , medicine , liver transplantation , transplantation , hepatitis c virus , hepatitis c , viral hepatitis , viral load , virology , virus , immunology
Hepatitis C virus (HCV) clearance post–liver transplantation is uncommon. This is a case report of a patient who, after liver transplantation, developed cholestatic hepatitis characterized by severe graft dysfunction, in conjunction with high viral load. This was, however, followed by viral clearance and normalization of allograft function. The clinical features of this case and the quasispecies patterns during the illness and the clearance periods are described. In addition, management implications in terms of immunosuppressive therapy are discussed.