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Is hyperammonemia really the true cause of altered neuropsychology, brain MR spectroscopy and magnetization transfer after an oral amino acid load in cirrhosis?
Author(s) -
Riggio Oliviero,
Efrati Cesare,
Masini Andrea,
Angeloni Stefania,
Merli Manuela
Publication year - 2003
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1053/jhep.2003.50388
Subject(s) - cirrhosis , medicine , clinical neuropsychology , neuropsychology , hyperammonemia , hepatic encephalopathy , psychiatry , cognition
In conclusion, the report is an important contribution to the brainswelling hypothesis of HE, but we have some doubts that all the alterationsobserved may be attributed merely to ammonia. Ammonia stillremains the “principal suspect” in the pathogenesis of HE, but theidentification of the “accomplices” continues to be an important areaof investigation. (Letter to the Editor