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Hepatitis C virus infection and incident type 2 diabetes
Author(s) -
Mehta Shruti H.,
Brancati Frederick L.,
Strathdee Steffanie A.,
Pankow James S.,
Netski Dale,
Coresh Josef,
Szklo Moyses,
Thomas David L.
Publication year - 2003
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1053/jhep.2003.50291
Subject(s) - medicine , type 2 diabetes , diabetes mellitus , hazard ratio , hepatitis c , population , cohort study , prospective cohort study , incidence (geometry) , hepatitis c virus , cohort , body mass index , relative risk , confidence interval , immunology , endocrinology , virus , environmental health , physics , optics
Although hepatitis C virus (HCV) infection is more common among adults with type 2 diabetes, it is uncertain whether HCV precedes the development of diabetes. Thus, we performed a prospective (case‐cohort) analysis to examine if persons who acquired type 2 diabetes were more likely to have had antecedent HCV infection when enrolled in a community‐based cohort of men and women between the ages of 44 and 65 in the United States (Atherosclerosis Risk in Communities Study [ARIC]). Among 1,084 adults free of diabetes at baseline, 548 developed diabetes over 9 years of follow‐up evaluation. Incident cases of diabetes were identified by using fasting glucose and medical history and HCV antibodies were assessed at baseline. A priori , persons were categorized as low‐risk or high‐risk for diabetes based on their age and body mass index, factors that appeared to modify the type 2 diabetes‐HCV infection incidence estimates. The overall prevalence of HCV in this population was 0.8%. Among those at high risk for diabetes, persons with HCV infection were more than 11 times as likely as those without HCV infection to develop diabetes (relative hazard, 11.58; 95% confidence interval, 1.39‐96.6). Among those at low risk, no increased incidence of diabetes was detected among HCV‐infected persons (relative hazard, 0.48; 95% confidence interval, 0.05‐4.40). In conclusion, pre‐existing HCV infection may increase the risk for type 2 diabetes in persons with recognized diabetes risk factors. Additional larger prospective evaluations are needed to confirm these preliminary findings.