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HBV superinfection in hepatitis C virus chronic carriers, viral interaction, and clinical course
Author(s) -
Sagnelli Evangelista,
Coppola Nicola,
Messina Vincenzo,
di Caprio Domenico,
Marrocco Cecilia,
Marotta Anna,
Onofrio Mirella,
Scolastico Carlo,
Filippini Pietro
Publication year - 2002
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1053/jhep.2002.36509
Subject(s) - superinfection , seroconversion , medicine , hbsag , virology , hepatitis b virus , hepatitis c virus , immunology , virus , gastroenterology
We enrolled 44 patients with hepatitis B virus (HBV) acute infection, 21 anti‐hepatitis C virus (HCV)–positive for at least 1 year (case BC group), 20 anti‐HCV–negative (control B group), and 3 with HBV/HCV acute concurrent infection. For each case BC, a subject with chronic HCV infection alone was selected (control C group). At the first observation, 85.7% of patients in case BC group and 85% of those in control B group were HBV‐DNA–positive (polymerase chain reaction [PCR]), with a similar trend towards a decrease and negativization in about 20 days; in the case BC group, seroconversion to antibody to hepatitis B e antigen (anti‐HBe) was more rapid. HCV‐RNA (PCR) was undetectable in all case BC patients but 1, who shortly became negative, whereas 85.7% of subjects in control C group were positive ( P < .001). Severe acute hepatitis was more frequent in the case BC group than in the control B group (28.6% vs. 0%, P < .05). Of the 14 patients in the case BC group and of the 16 in the control B group followed up for more than 6 months, 1 in the first and 1 in the second group became hepatitis B surface angiten (HBsAg) chronic carriers. Of the 13 patients in case BC group who recovered, 1 cleared both anti‐HCV and HCV‐RNA, 6 became HCV‐RNA–positive, and 6 remained HCV‐RNA–negative. In patients with HBV/HCV acute concurrent infection, HBV‐DNA became undetectable in 15 days, and HCV‐RNA and anti‐HCV became positive at days 30 and 45, respectively; these patients developed HCV‐RNA–positive chronic hepatitis. In conclusion, HBV superinfection in chronic HCV carriers has a severe clinical course and strongly and persistently depresses HCV.