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Inefficacy of high‐dose transdermal fentanyl in a patient with neuropathic pain a case report
Author(s) -
Bleeker Chris P.,
Bremer Robbert C.,
Dongelmans Dave A.,
Dongen Robert T.M.,
Crul Ben J.P.
Publication year - 2001
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1053/eujp.2000.0220
Subject(s) - fentanyl , medicine , transdermal , dose , anesthesia , pain relief , neuropathic pain , depression (economics) , breakthrough pain , opioid , transdermal patch , pharmacology , receptor , economics , macroeconomics
Pain partially responsive to opioids can lead to rapid escalating dosages due to tolerance development. In this report the case of a 58‐year‐old female with neuropathic pain using increasing transdermal (TTS) fentanyl dosages to a maximum dose of 3400 μg/h resulting in fentanyl plasma levels of 173 ng/ml is described. For pain relief an epidural infusion at the level T1–2 with bupivacaine was started. Immediate pain relief was accompanied by short lasting respiratory depression and drowsiness.