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Lumbar catheterization of the subarachnoid space with a 32‐gauge polyurethane catheter in the rat
Author(s) -
Pogatzki Esther M.,
Zahn Peter K.,
Brennan Timothy J.
Publication year - 2000
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1053/eujp.1999.0157
Subject(s) - subarachnoid space , catheter , medicine , anesthesia , intrathecal , lumbar , lidocaine , surgery , cerebrospinal fluid
Chronic catheterization of the subarachnoid space of rats is an important tool for intrathecal drug delivery in pharmacologic investigations of pain. We describe a technique using direct lumbar insertion of a small 32‐gauge polyurethane (PU) catheter without extensive surgery. Location of the catheter was confirmed with 2% lidocaine injection 1 day later, and methylene blue injection after 7–14 days. This method improved recovery of the rat after catheter implantation and reduced neurologic complications. Copyright 2000 European Federation of Chapters of the International Association for the Study of Pain