Open AccessEnhanced bactericidal activity of azithromycin‐coated silver nanoprisms in comparison to their spherical‐shaped counterparts
Author(s) -
Yaqub Atif,
Ali Sharafat,
Ditta Sarwar Allah,
Tanvir Fouzia,
Ali Shaista,
Naz Misbah
Publication year - 2020
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2019.0704
Subject(s) - azithromycin , materials science , nanotechnology , chemistry , microbiology and biotechnology , biology , antibiotics
Human beings have been bearing great medical, social, and economic losses due to the ever‐increasing rate of microbial infections and the development of resistance; hence, there is a dire need to develop novel strategic alternate tools to circumvent these infections. In this regard, metallic nanomaterials (NMs) have been reported to exhibit promising bactericidal properties. In the present study, two different shaped silver NMs, i.e. silver nanoparticles (AgNPs) and silver nanoprisms (AgNPrs) and their conjugates with azithromycin were synthesised, characterised, and tested for their bactericidal activity. The average particle sizes analysed for spherical nanoparticles were 30–47.5 nm, and for prismatic‐nanoparticles was 35–60 nm, respectively. The distinct ultraviolet–visible peaks were obtained for NMs and their nanoconjugates. The results of Fourier transform infrared spectroscopy indicated the interaction of various functional groups from Azy with metallic NMs. The nanoprisms and their conjugates showed enhanced bactericidal potential as compared to AgNPs and their corresponding control. The efficiency of Azy–AgNPrs was statistically higher ( P <0.05) than AgNPs, Azy–AgNPs, and AgNPrs against the growth of Escherichia coli and Staphylococcus aureus . These results can be used as an innovative tool for further in‐depth optimisation of shape‐dependent nanoconjugates for their bactericidal activity.