Open AccessSurface‐enhanced Raman spectroscopy with gold nanoparticle dimers created by sacrificial DNA origami technique
Author(s) -
Yamashita Naoki,
Park Seongsu,
Kawai Kentaro,
Hirai Yoshikazu,
Tsuchiya Toshiyuki,
Tabata Osamu
Publication year - 2020
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2019.0416
Subject(s) - dna origami , colloidal gold , raman spectroscopy , materials science , ultrapure water , surface enhanced raman spectroscopy , nanoparticle , nanotechnology , substrate (aquarium) , molecule , silicon , raman scattering , chemistry , nanostructure , optoelectronics , optics , organic chemistry , oceanography , geology , physics
In a previously proposed method for molecular detection based on surface‐enhanced Raman spectroscopy (SERS), gold nanoparticle (AuNP) dimers are formed on a substrate using DNA origami with a nanometre‐scale gap between them. In this sacrificial DNA origami technique, a conjugate of two AuNPs and a DNA origami is deposited on a silicon chip, and then the DNA origami is selectively removed using vacuum ultraviolet light and ultrapure water rinsing to form surface‐clean AuNP dimers. The performance of SERS‐based molecular detection of AuNP dimers created using the proposed technique with a 30 nm AuNP diameter has now been evaluated. The Raman signals from the target molecules (4,4′‐bipyridine) were greatly enhanced and thus successfully detected.