Open AccessGlutathione and pH serial responsive functional mesoporous silica nanoparticles for drug delivery
Author(s) -
He Liang,
Nan Xueyan,
Wang Tong,
Bai Pengli
Publication year - 2020
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2019.0317
Subject(s) - mesoporous silica , drug delivery , hyaluronic acid , nanoparticle , chitosan , glutathione , drug , nanotechnology , chemistry , materials science , mesoporous material , combinatorial chemistry , pharmacology , organic chemistry , catalysis , medicine , anatomy , enzyme
In this work, a novel glutathione and pH serial dual‐responsive drug delivery system has been developed, which was constructed with chitosan (CS), carbon dots (CDs) and hyaluronic acid (HA) modified the mesoporous silica nanoparticles (MSNs). The system showed excellent drug loading efficiency, controlled release and targeted delivery. In addition, the platform (MSN‐CS@HA‐CDs) exhibited fluorescence imaging property. The prepared drug delivery system appeared to be a promising cancer treatment platform.