Glutathione and pH serial responsive functional mesoporous silica nanoparticles for drug delivery | Zendy

He Liang | Zendy; Nan Xueyan | Zendy; Wang Tong | Zendy; Bai Pengli | Zendy

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Glutathione and pH serial responsive functional mesoporous silica nanoparticles for drug delivery

Author(s) -

He Liang,

Nan Xueyan,

Wang Tong,

Bai Pengli

Publication year - 2020

Publication title -

micro and nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.25

H-Index - 31

ISSN - 1750-0443

DOI - 10.1049/mnl.2019.0317

Subject(s) - mesoporous silica , drug delivery , glutathione , nanoparticle , nanotechnology , chemistry , drug , mesoporous material , pharmacology , materials science , biochemistry , medicine , catalysis , enzyme

In this work, a novel glutathione and pH serial dual‐responsive drug delivery system has been developed, which was constructed with chitosan (CS), carbon dots (CDs) and hyaluronic acid (HA) modified the mesoporous silica nanoparticles (MSNs). The system showed excellent drug loading efficiency, controlled release and targeted delivery. In addition, the platform (MSN‐CS@HA‐CDs) exhibited fluorescence imaging property. The prepared drug delivery system appeared to be a promising cancer treatment platform.

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