Open AccessMagnetic/pH dual‐responsive nanocomposites loading doxorubicin hydrochloride for cancer therapy
Author(s) -
Zhang Tingting,
Zhang Kun,
Jiang Feng,
Zhang Jianfeng,
Song Xin,
Zhao Jinshun
Publication year - 2019
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2018.5541
Subject(s) - nanocomposite , materials science , doxorubicin hydrochloride , nuclear chemistry , chemical engineering , nanotechnology , chemistry , doxorubicin , medicine , surgery , engineering , chemotherapy
Development of stimuli‐responsive nanocomposites for the delivery anticancer drug has attracted considerable attention. A magnetic/pH dual‐responsive nanocomposite was synthesised by amide condensation reaction and developed for cancer therapy. The PEGylated citric‐coated Fe 3 O 4 (PCI)–graphene oxide (GO) nanocomposites was constructed by a three‐step process. Fe 3 O 4 magnetic nanoparticles were firstly coated with citric acid, and then covalently linked to aminated polyethylene glycol (NH 2 –PEG–NH 2 ); lastly, the PCI was covalently conjugated to graphite oxide to obtain PCI–GO nanocomposites. The PCI–GO nanocomposites were characterised by X‐ray diffraction, scanning electron microscopy, Fourier transform‐infrared, ultraviolet–visible, and thermogravimetry. The magnetic of nanocomposites was confirmed by a vibrating sample magnetometer. Due to the hydrogen bond, π – π stacking and electrostatic interaction between the doxorubicin (DOX) hydrochloride and PCI–GO nanocomposites, the PCI–GO nanocomposites could load DOX effectively and with a high drug loading content (about 87.6%). The DOX‐loaded PCI–GO (DOX/PCI–GO) nanocomposites exhibited pH‐responsive release behaviour. The DOX/PCI–GO nanocomposites could effectively inhibit tumour growth in vitro, which was comparable to the antitumour effect of free DOX. The result indicates that the PCI–GO nanocomposites exhibit great potential for a magnetic targeted drug delivery system in multimodal and synergistic cancer therapy.