Open AccessApproach to the preparation of temperature‐sensitive poly(N‐isopropylacrylamide)/polyethylenimine microgel
Author(s) -
Wang Tao,
Song Yanan,
Hu Jiawei,
Li Jiaxi,
Shi Shan
Publication year - 2019
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2018.5359
Subject(s) - polyethylenimine , poly(n isopropylacrylamide) , macromonomer , polymer chemistry , acrylic acid , copolymer , materials science , lower critical solution temperature , aqueous solution , chemical engineering , chemistry , polymer , organic chemistry , composite material , transfection , biochemistry , engineering , gene
A novel route was developed to the preparation of temperature‐sensitive poly(N‐isopropylacrylamide)/polyethylenimine (PNIPAM/PEI) microgels by the radical copolymerisation of N‐isopropylacrylamide with acryloylated PEI in aqueous media. Here, the acryloylated polyethylenimine (PEI), used as a macromonomer, was synthesised by a dehydration condensation reaction between PEI and acrylic acid. The as‐prepared microgels exhibited well‐defined core/shell structure with PNIPAM‐rich core surrounded by PEI‐rich shell. The microgels showed the volume phase transition temperature near physiological temperature, which can be easily regulated by the pH of microgel dispersion.