Open AccessApplication of β ‐CD/HA composite as a potential SD carrier to improve the dissolution of curcumin
Author(s) -
Xu Defeng,
Wang Wenjie,
Yang Mengmeng,
Bhaduri Sarit B.,
Huang Chingcheng,
Yang Lei,
Zhang Zhenyi,
Zhou Huan
Publication year - 2019
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2018.5096
Subject(s) - curcumin , dissolution , chemistry , nuclear chemistry , fourier transform infrared spectroscopy , solvent , transmission electron microscopy , chromatography , chemical engineering , materials science , nanotechnology , organic chemistry , biochemistry , engineering
Curcumin is a natural active constituent with a great variety of beneficial biological and pharmacological activities, is a practically water‐insoluble component. The scope of the present work was to prepare a solid dispersion (SD) formulation to enhance the dissolution rate of curcumin. The SD was prepared using curcumin and β ‐cyclodextrin (CD)/HA via a classical ethanol‐based solvent evaporation method. The as‐prepared β ‐CD/HA and SDs were selectively characterised by various analytical techniques including X‐ray diffraction, transmission electron microscopy, scanning electron microscopy, specific surface area/pore size analysis, Fourier transform infrared spectroscopy, and high‐performance liquid chromatography. According to the dissolution tests, it was confirmed that β ‐CD/HA–curcumin SD can significantly enhance the dissolution of curcumin. In addition, an increasing trend was seen between the β ‐CD weight ratio and the dissolution rate of curcumin, and β ‐CD/HA–curcumin (9:1) SD was shown to be the best formulation among all tested samples with over 90% curcumin dissolved in 180 min. Besides, β ‐CD/HA–curcumin (9:1) SD exhibited pH and medium‐dependent curcumin release behaviours. The antioxidant activity of released curcumin showed no difference to original curcumin. These results clearly demonstrated β ‐CD/HA can be a promising SD carrier to improve the dissolution of curcumin.