Open AccessFabrication and characterisation of new type of magnetic nanoanion exchanger particles for enteric losartan potassium delivery
Author(s) -
Amareh Nazanin,
Ahmad Panahi Homayon,
Moeinpour Farid
Publication year - 2018
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2018.0141
Subject(s) - freundlich equation , thermogravimetric analysis , losartan potassium , sorption , chemistry , langmuir , nuclear chemistry , potassium , magnetic nanoparticles , ion exchange , nanoparticle , chromatography , adsorption , losartan , inorganic chemistry , materials science , organic chemistry , nanotechnology , angiotensin ii , biochemistry , ion , receptor
Magnetite nanoparticles (MNPs) were synthesised and grafted with polymer containing brilliant cresyl blue for the exchange of losartan potassium. The resulted polymeric nanoparticles were characterised with Fourier transform infrared spectroscopy, elemental analysis, thermogravimetric analysis and transmission electron microscopy. The effects of the exchange parameters such as sample pH, temperature and contact time on sorption of losartan potassium were investigated. The sorption capacity of the functionalised sorbent was 19.4 mg g −1 . The equilibrium adsorption data of losartan potassium on modified nanoparticles were analysed by Langmuir, Freundlich, Temkin, Dubinin–Radushkevich and Redlich–Peterson equations. Nearly, 74% of losartan potassium was released in simulated gastric fluid of pH 1.2 in 15 h and 50% in simulated intestinal fluid pH 7.4 in 30 h. These results have shown the utility of losartan potassium loaded–modified MNPs for enteric drug delivery.