Open AccessPreparation and characterisation of ginkgolide nanoparticles via the emulsion solvent evaporation method
Author(s) -
Jiang Jianfang,
Ao Juan,
He Chunyang,
Xiong Jun,
Zhao Jiaqi,
Liu Jintao,
You Shengrong,
Jiang Hao
Publication year - 2018
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2017.0906
Subject(s) - zeta potential , dispersity , nanoparticle , solvent , particle size , emulsion , nanomaterials , evaporation , nanometre , chemistry , nanotechnology , materials science , yield (engineering) , nuclear chemistry , chemical engineering , organic chemistry , composite material , physics , engineering , thermodynamics
Ginkgolide is the first choice for treatment of cardiovascular and cerebrovascular diseases. However, its conventional dosage form (ginkgolide injection) can easily produce side effects and adverse reactions. Hence, developing a new, safe and efficient nanometre dosage form is imperative. Ginkgolide nanoparticles (GLNs) were prepared via the emulsion solvent evaporation method, and their mean hydrodynamic diameter, surface zeta potential, and surface morphology were characterised. The work studied four factors that were able to influence the properties of GLNs and discussed the preparation mechanism. The results showed that the prepared GLNs were nanomaterials. The optimum preparation conditions were with a W/O of 5.0, C PVA of 6.0%, P of 250 W and T of 4.0 min. The GLN that was prepared under optimum conditions exhibited good dispersity and stability. Its surface zeta potential was −20.97 mV, single particle size was 20–50 nm, and the preparation yield was 73.51%. The pharmacokinetics of GLN was studied in detail, and the C max and AUC 0→∞ increased by 63.29 and 67.56%, respectively, compared with ginkgolide injection. This study lays a foundation for the research and development of new nano‐dosage forms of ginkgolide and has an important value.