Open AccessAlbumin nanoparticles fabricated from microscaled PLGA templates using layer‐by‐layer assembly
Author(s) -
Zhao Qi,
Fang ZheXiang,
Chen MingMao,
Li Min,
Zhou ZhiMin,
Du Bo,
Zhang QiQing
Publication year - 2018
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2017.0696
Subject(s) - plga , sonication , nanoparticle , layer by layer , template , materials science , chemical engineering , glycolic acid , layer (electronics) , albumin , nanotechnology , chemistry , chromatography , lactic acid , biochemistry , biology , bacteria , engineering , genetics
The size of particles is a principal parameter to design drug delivery vehicles. In this work, albumin nanoparticles were fabricated from microscaled poly[lactic‐co‐(glycolic acid)] (PLGA) templates using layer‐by‐layer (LbL) assembly, which are different from traditional LbL‐based hollow capsules. The albumin nanoparticles exhibit a spherical shape and solid inner structure. The formation mechanism of these albumin nanoparticles was proposed based on PLGA templates, mechanical property of albumin and external sonication.