Open AccessPreparation, characterisation, drug loading and release properties of a novel KIT‐6/poly(AA‐EGDMA) nanocomposite
Author(s) -
Shafiei Anahita,
Yahya S.,
Beheshtiha Sh.,
Heravi Majid M.,
Kalbasi Roozbeh Javad
Publication year - 2018
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2017.0451
Subject(s) - ethylene glycol dimethacrylate , materials science , fourier transform infrared spectroscopy , nanocomposite , thermogravimetric analysis , nuclear chemistry , acrylic acid , scanning electron microscope , polymer chemistry , polymer , polymerization , chemical engineering , copolymer , chemistry , methacrylic acid , composite material , engineering
A KIT‐6/poly(acrylic acid‐ethylene glycol dimethacrylate) (KIT‐6/Poly(AA‐EGDMA) nanocomposite was synthesised as an adequate carrier. KIT‐6 as a three‐dimensional cubic symmetric structure was prepared by the sol–gel method. Polymerisation was carried out through the in situ method in which EGDMA was cross‐linked by AA inside KIT‐6 pores. This mesostructure acts as a smart uptake and release of the ibuprofen (IBU) system. Diverse characterisation techniques including Fourier transform infrared spectroscopy, X‐ray powder diffraction, Brunauer–Emmett–Teller, thermal gravimetric, scanning electron microscopy and ultraviolet‐visible spectroscopy were employed to determine the relationship between the carrier nature and drug release performance. The KIT‐6/Poly(AA‐EGDMA) was modified by changing the ratio of the polymer and IBU as well as its time‐loading. The results proved that the KIT‐6/Poly(AA‐EGDMA) has the ability of drug adsorption and slow release in a simulated body fluid.